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B4311

Sigma-Aldrich

BF-170 hydrochloride

≥98% (HPLC), solid

Synonym(s):

2-(4-aminophenyl)quinoline hydrochloride, NSC 168387 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H12N2 · HCl
CAS Number:
22191-97-5
Molecular Weight:
256.73
MDL number:
MFCD08705340
UNSPSC Code:
12352200
PubChem Substance ID:
24891766
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated
protect from light
under inert gas

color

orange

solubility

H2O: 10 mg/mL

storage temp.

−20°C

SMILES string

Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2

InChI

1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H

InChI key

UYYPMQOFLJHJAW-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.

Caution

Product is air sensitive, store under inert gas.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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