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C002

Sigma-Aldrich

(±)-Quinuclidinyl benzilate

powder

Synonym(s):

(±)-QNB, (±)-Quinuclidinyl α-hydroxydiphenylacetate

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About This Item

Empirical Formula (Hill Notation):
C21H23NO3
CAS Number:
6581-06-2
Molecular Weight:
337.41
MDL number:
MFCD00055094
UNSPSC Code:
12352200
PubChem Substance ID:
329774757
NACRES:
NA.77

form

powder

Quality Level

100

color

white

solubility

chloroform: soluble (but decomposes within 24 hrs)
methanol: stable (for up to two weeks at -20°C.)

εmax

13,500 at 207.4 nm in methanol

storage temp.

2-8°C

SMILES string

OC(C(=O)OC1CN2CCC1CC2)(c3ccccc3)c4ccccc4

InChI

1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2

InChI key

HGMITUYOCPPQLE-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Nonselective muscarinic acetylcholine receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Monica Salani et al.
Journal of neurochemistry, 108(3), 821-834 (2009-02-04)
Neurotransmitters are considered part of the signaling system active in nervous system development and we have previously reported that acetylcholine (ACh) is capable of enhancing neuronal differentiation in cultures of sensory neurons and N18TG2 neuroblastoma cells. To study the mechanism
José N Nobrega et al.
Journal of pharmacological and toxicological methods, 86, 28-33 (2017-03-10)
Assessments of total anticholinergic activity (SAA) in serum are of considerable interest for its potential involvement in cognitive impairment associated with polydrug states in the elderly and other populations. Such estimations have been based on the displacement of radioligand binding
Koji Hori et al.
Neuropsychobiology, 63(3), 147-153 (2011-01-14)
Alzheimer's disease (AD) is well known as a disease characterized by degeneration of cholinergic neuronal activity in the brain. It follows that patients with AD would be sensitive to an 'anticholinergic burden', and also that medicine with anticholinergic properties would
Kylie J Mansfield et al.
The Journal of pharmacology and experimental therapeutics, 328(3), 893-899 (2008-11-26)
Recent studies have described muscarinic receptors on the mucosa and the detrusor of the human urinary bladder. Muscarinic receptor antagonists are effective in the treatment of overactive bladder (OAB), but their site(s) of action and actual therapeutic target are unclear.
Barbara C van Munster et al.
Journal of psychiatric research, 46(10), 1339-1345 (2012-08-01)
Delirium, a frequently occurring, devastating disease, is often underdiagnosed, especially in dementia. Serum anticholinergic activity (SAA) was proposed as a disease marker as it may reflect delirium's important pathogenetic mechanism, cholinergic deficiency. We assessed the association of serum anticholinergic activity
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