C1399
Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse
clone KS-B17.2, ascites fluid
Synonym(s):
Anti-CK18
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About This Item
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biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
KS-B17.2, monoclonal
contains
15 mM sodium azide
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect immunofluorescence: 1:100 using formalin-fixed, paraffin-embedded sections of human tissue
microarray: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KRT18(3875)
General description
Monoclonal anti-Cytokeratin Peptide 18 (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Specificity
The antibody reacts with a wide variety of simple epithelia (gastrointestinal, respiratory, urinary, liver, and glandular) but does not react with most stratified squamous epithelium (esophagus, epidermis) or non-epithelial cells.
Immunogen
keratin from the bovine mammary gland epithelial cell line BMGE.
Application
Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse has been used in:
- immunofluorescence
- immunoperoxidase staining
- immunocytochemistry
- microarray
Biochem/physiol Actions
Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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flash_point_c
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Certificates of Analysis (COA)
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B Lifschitz-Mercer et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 8(4), 349-356 (1989-01-01)
Cytoskeletal typing of five chorangiomas revealed diffuse staining of the blood vessels with antibodies to vimentin and to alpha smooth muscle (alpha-SM) actin, while cytokeratin 18 decorated the blood vessels focally. Focal staining for desmin was observed in two chorangiomas.
The identification and localization of two intermediate filament proteins in the tunic of Styela plicata (Tunicata, Styelidae).
Di Bella MA, et al.
Tissue & cell, 41(6), 381-389 (2009)
J Mühlhauser et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 43(6), 579-589 (1995-06-01)
Cytokeratins (CKs) are related to proliferation and differentiation of epithelial cells. Little knowledge exists about CK patterns in human trophoblast subpopulations (villous and extravillous trophoblasts). To better understand differentiation and function of trophoblast components, we studied the distribution patterns of
B Kaeffer et al.
Cell biology international, 21(5), 303-314 (1997-05-01)
We have studied the effect of sodium orthovanadate, an inhibitor of protein tyrosine phosphatases, on primary cultures of colonocytes and stromal cells. Everted proximal and distal colonic tissue of adult rats were disintegrated by a collagenase/dispase solution for 60 min
P H Chen et al.
Journal of virology, 67(6), 3507-3514 (1993-06-01)
Immunofluorescence studies revealed that adenovirus induces a reorganization of the cytokeratin system in lytically infected HeLa cells. At 24 h postinfection, the cytokeratin network began to disassemble into prominent spheroid globules. By 36 h postinfection, host cell lysis occurred, accompanied
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