E0643
Erythropoietin Soluble Receptor human
>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonym(s):
EPO sR
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About This Item
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biological source
human
Quality Level
recombinant
expressed in NSO cells
assay
>90% (SDS-PAGE)
form
lyophilized powder
potency
74 ng/mL
mol wt
~25 kDa
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... EPOR(2057)
Biochem/physiol Actions
Recombinant human soluble erythropoietin receptor binds erthropoietin with high affinity and is an erythropoietin antagonist.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose and 50 ug of bovine serum albumin per 1 ug of cytokine.
Analysis Note
The biological activity is measured by its ability to inhibit the recombinant human erythropoietin mediated cell proliferation of human TF1 cells.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Soluble Erythropoietin Receptor Contributes To Erythropoietin Resistance In End-stage Renal Disease.
Khankin, E.V., et al.
PLoS Biology, 5, e9246-e9246 (2010)
T Kitamura et al.
Journal of cellular physiology, 140(2), 323-334 (1989-08-01)
We have established a novel cell line, designated as TF-1, from a patient with erythroleukemia, which showed complete growth dependency on granulocyte-macrophage colony-stimulating factor (GM-CSF) or on interleukin-3 (IL-3) and carried a homogeneous chromosomal abnormality (54X). Erythropoietin (EPO) also sustained
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