Skip to Content
MilliporeSigma
All Photos(3)

Documents

E5750

Sigma-Aldrich

Ergocalciferol

40,000,000 USP units/g

Synonym(s):

Calciferol, Ercalciol, Ergosterol irradiated, Irradiated ergosterol, Vitamin D2

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C28H44O
CAS Number:
50-14-6
Molecular Weight:
396.65
Beilstein/REAXYS Number:
1916682
EC Number:
200-014-9
MDL number:
MFCD00166988
UNSPSC Code:
12352205
eCl@ss:
34058017
PubChem Substance ID:
24894344
NACRES:
NA.79

biological source

synthetic (organic)

Quality Level

200

assay

≥97%

form

powder

specific activity

40,000,000 USP units/g

technique(s)

HPLC: suitable

color

white to off-white

mp

114-118 °C (lit.)

storage temp.

2-8°C

SMILES string

CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

InChI

1S/C28H44O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-20,22,25-27,29H,4,7-8,11,14-18H2,1-3,5-6H3/b10-9+,23-12+,24-13-/t20-,22+,25-,26+,27-,28+/m0/s1

InChI key

MECHNRXZTMCUDQ-RKHKHRCZSA-N

Gene Information

human ... VDR(7421)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Vitamin D2 or ergocalciferol is available through dietary supplements or plant sources. It is a provitamin, which is fat-soluble.

Application

Ergocalciferol has been used as a component of the diet for rats, to study its bioavailability from ultraviolet-irradiated D2-rich yeast. It has also been used as a standard for identification and quantification of vitamins, as part of a study to determine the nutritional composition of food fishes.

Biochem/physiol Actions

Ergocalciferol (vitamin D2) and 25-Hydroxycholecalciferol (vitamin D3) are the two forms of vitamin D, which are activated in vivo by hydroxylation. Vitamin D2 and D3 may be used in a wide range of studies to assess their effects on function such as immune function and calcium homeostasis.
Ergocalciferol is used for antirachitic treatment. Vitamin D has an active role in bone mineralization. Severe deficiency of this vitamin has been associated with osteomalacia and rickets.

Packaging

Sealed ampule.

Quantity

1 USP unit = 1 I.U.

related product

Product No.
Description
Pricing

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 6

1 of 6

Cholecalciferol meets USP testing specifications

Sigma-Aldrich

C1357

Cholecalciferol

Guanine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1243

Guanine

Vitamin D₃ (cholecalciferol) cryst. (1 g = 40 Mio.I.U.) EMPROVE® ESSENTIAL, Ph. Eur., BP, USP

SAFC

5.00936

Vitamin D₃ (cholecalciferol) cryst. (1 g = 40 Mio.I.U.)

Cholecalciferol (Vitamin D3) Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1237

Cholecalciferol (Vitamin D3)

Vitamin D2 solution 100 μg/mL in ethanol, 98% (CP)

Sigma-Aldrich

740306

Vitamin D2 solution

Vitamin D2 solution 1 mg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-024

Vitamin D2 solution

Rock E
Food for the Ageing Population (2009)
Vitamin D: The Biotechnology of Ergosterol
Vandamme EJ
Biotechnology of microbial enzymes (1989)
Poor bioavailability of vitamin D2 from ultraviolet-irradiated D2-rich yeast in rats
Itkonen ST, et al.
Nutrition Research (New York, N.Y.), 59, 36-43 (2018)
Dietary Reference Intakes for Calcium and Vitamin D (2011)
Nutritional composition of food fishes and their importance in providing food and nutritional security
Mohanty BP, et al.
Food Chemistry, 293 (2019)
View All Related Papers

Articles

Vitamin D and Prevention of Human Disease

Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniquely initiated in the skin of vertebrates. During sun exposure, ultraviolet B photons are absorbed by 7-dehydrocholesterol, which is found within the plasma membranes of epidermal and dermal skin layers. This reaction yields an unstable derivative of 7-dehydrocholesterol, named precholecalcitrol, which rapidly rearranges to vitamin D3. Vitamin D binding protein (DBP) is a carrier protein responsible for drawing vitamin D3 from the plasma membrane into the dermal capillaries within the extracellular space.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service