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EMU033231

Sigma-Aldrich

MISSION® esiRNA

targeting mouse Igfbp2

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About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

ATGTTGGGAGGTGGTAGCAGTGCTGGCCGGAAGCCCCTCAAGTCAGGCATGAAGGAGCTGGCTGTGTTCCGGGAGAAGGTCAATGAACAGCACCGGCAGATGGGCAAGGGTGCCAAACACCTCAGTCTGGAGGAGCCCAAGAAGTTGCGCCCGCCTCCCGCCAGGACCCCTTGCCAGCAGGAGTTGGACCAGGTCCTGGAGCGGATCTCCACCATGCGCCTTCCGGATGATCGGGGCCCCCTGGAACATCTCTACTCCCTGCACATCCCCAACTGTGACAAGCATGGCCGGTACAACCTTAAGCAGTGCAAGATGTCTCTGAACGGACAGCGCGGGGAGTGCTGGTGTGTGAACCCCAACACCGGGAAGCCCATCCAGGGAGCTCCCACCATCCGGGGAGACCCCGAGTGCCATCTCTTCTACAACGAGCAGCAGGAGACTGGTGGGGCCCATGCCCAAAGTGTGCAGTAAACCCCAGC

Ensembl | mouse accession no.

ENSMUSG00000039323

NCBI accession no.

NM_008342

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... IGFBP2(16008) , Igfbp2(16008)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

flash_point_f

Not applicable

flash_point_c

Not applicable

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S W Yau et al.
International journal of obesity (2005), 39(5), 770-781 (2014-11-06)
IGF-binding protein (IGFBP)-2 is the principal IGFBP produced by white adipocytes during adipogenesis, and circulating levels are reduced in obesity. Overexpression of IGFBP-2 in transgenic mice prevents obesity, but depot-specific effects of IGFBP-2 on adipo/lipogenesis are unknown. The present study
Steven W Yau et al.
Endocrinology, 155(6), 2133-2143 (2014-03-25)
Leptin is produced from white adipose tissue and acts primarily to regulate energy balance. Obesity is associated with leptin resistance and increased circulating levels of leptin. Leptin has recently been shown to influence levels of IGF binding protein-2 (IGFBP-2), a

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