G0166
Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert C1) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
antigen 100 kDa
species reactivity
rat, mouse
packaging
antibody small pack of 25 μg
technique(s)
immunohistochemistry (frozen sections): 1:1000-1:2000
western blot: 1:1000 using rat and mouse tissue
UniProt accession no.
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
mouse ... Grin1(14810)
rat ... Grin1(24408)
Related Categories
Immunogen
synthetic peptide representing the sequence of the C1 splice variant.
Application
Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert C1) antibody is suitable for immunohistochemistry (frozen sections) at a dilution of 1:1000-1:2000 and western blot at 1:1000 dilution using rat and mouse tissue.
Biochem/physiol Actions
NMDA receptors (NMDAR) are glutamate-gated ion channels. It is sensitive to N-methyl-D-aspartate (NMDA) and consists of several homologous subunits (NMDAR1). NMDAR is highly expressed in the central nervous system and involved in excitatory synaptic transmission as well as synaptic plasticity. The activity of NMDA receptors are modulated by glycine. It exhibits high calcium permeability and unique voltage-dependent sensitivity to magnesium. It has been reported that phosphorylated NMDA receptors may regulate their function and play a role in many forms of synaptic plasticity such as long-term potentiation.
Physical form
Lyophilized powder from 5 mM ammonium bicarbonate, so some residual salt may be present
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Tue G Banke et al.
Nature neuroscience, 6(2), 144-152 (2003-01-14)
N-methyl-D-aspartate (NMDA) receptors are highly expressed in the central nervous system and are involved in excitatory synaptic transmission as well as synaptic plasticity. Despite considerable structural and biophysical research, the mechanism behind activation of the NMDA receptor is still poorly
R S Zukin et al.
Trends in neurosciences, 18(7), 306-313 (1995-07-01)
Molecularly diverse forms of the NMDA-receptor subunit NRI are formed by alternative RNA splicing. Differential splicing of three exons generates as many as eight NRI splice variants, seven of which have been identified in cDNA libraries. The alternatively spliced exons
R L Foldes et al.
Gene, 147(2), 303-304 (1994-09-30)
Two cDNA clones representing previously unidentified human N-methyl-D-aspartate receptor (hNR1) subunit polypeptides were isolated and sequenced. Clone hNR1-4 was isolated from a human hippocampus cDNA library and was presumably generated by alternative RNA splicing in the 3' amino acid (aa)
K Moriyoshi et al.
Nature, 354(6348), 31-37 (1991-11-07)
A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant
W G Tingley et al.
Nature, 364(6432), 70-73 (1993-07-01)
The NMDA (N-methyl D-aspartate) receptors in the brain play a critical role in synaptic plasticity, synaptogenesis and excitotoxicity. Molecular cloning has demonstrated that NMDA receptors consist of several homologous subunits (NMDAR1, 2A-2D). A variety of studies have suggested that protein
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