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GW20030F

Sigma-Aldrich

Anti-β-2-Microglobulin antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-B2MG

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About This Item

MDL number:
MFCD00162400
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-20030F

technique(s)

western blot: suitable

NCBI accession no.

NP_004039.1

UniProt accession no.

P61769

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... B2M(567)

Immunogen

β-2-Microglobulin native protein.
Immunogen Sequence: GI # 4757826, sequence 1-119

Application

Anti-β-2-Microglobulin antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.

Biochem/physiol Actions

β-2-Microglobulin is a serum protein that forms a non-covalent association with the heavy chain of the major histocompatibility complex (MHC) class I, which is involved in the presentation of peptide antigens to the immune system. Defects in this gene can cause hypercatabolic hypoproteinemia. Amyloidosis is caused upon polymerization of intact β 2-microglobulin in patients on chronic hemodialysis.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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wgk_germany

WGK 1

flash_point_f

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flash_point_c

Not applicable

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Certificates of Analysis (COA)

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P D Gorevic et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(20), 7908-7912 (1986-10-01)
Systemic amyloidosis with a predilection for bone and synovium may complicate the course of patients on long-term hemodialysis. This form of amyloidosis can be typed as distinct from other amyloid diseases by using small tissue samples obtained by bone biopsy
C Bernabeu et al.
Nature, 308(5960), 642-645 (1984-04-12)
Beta 2-microglobulin (beta 2-m) is a highly conserved polypeptide (12,000 molecular weight; 12K) noncovalently associated with the heavy chain (45-48K) of the major histocompatibility complex (MHC) class I antigens. Its synthesis is required for expression of the HLA-A/B and H-2K/D
Manzoor A Wani et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(13), 5084-5089 (2006-03-22)
Two siblings, products of a consanguineous marriage, were markedly deficient in both albumin and IgG because of rapid degradation of these proteins, suggesting a lack of the neonatal Fc receptor, FcRn. FcRn is a heterodimeric receptor composed of a nonclassical

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