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H4413

Sigma-Aldrich

Hydroxyfasudil hydrochloride hydrate

≥98% (HPLC), solid

Synonym(s):

1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C14H17N3O3S · HCl · xH2O
CAS Number:
155558-32-0
Molecular Weight:
343.83 (anhydrous basis)
MDL number:
MFCD06411567
UNSPSC Code:
12352200
PubChem Substance ID:
24724499
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

composition

The two peaks show the equilibrim between the two tautomers

color

white

solubility

H2O: >5 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].Oc1nccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H

InChI key

XWWFOUVDVJGNNG-UHFFFAOYSA-N

Application

Hydroxyfasudil hydrochloride hydrate has been used as a ROCK inhibitor to study the role of different signaling pathways in the chemokines CCL19 and CCL21, the CCR7 ligands mediated effects on migratory and prosurvival, in CLL cells.

Biochem/physiol Actions

Hydroxyfasudil possessantispastic action. It is an active metabolite of fasudil. Hydroxyfasudil might enhance the dynamics of blood flow and prevent damage caused by neutrophils.
Rho-kinase inhibitor.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage
Satoh SI, et al.
Life Sciences, 69(12), 1441-1453 (2001)
Analysis of migratory and prosurvival pathways induced by the homeostatic chemokines CCL19 and CCL21 in B-cell chronic lymphocytic leukemia
Cuesta-Mateos C, et al.
Experimental Hematology, 38(9), 756-764 (2010)
Ghulam Mohammad et al.
Annals of clinical and laboratory science, 48(2), 137-145 (2018-04-22)
To investigate the effects of blocking Rho kinase pathway on the expression of inflammatory signaling pathways in the retina of diabetic mice and in human retinal Müller glial cells stimulated with high-glucose to replicate hyperglycemia. Retinas from diabetic mice and

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