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H4663

Sigma-Aldrich

HMBA

≥98% (HPLC), solid

Synonym(s):

10-[(3-Hydroxy-4-methoxybenzylidene)]-9(10H)-anthracenone

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About This Item

Empirical Formula (Hill Notation):
C22H16O3
CAS Number:
564468-51-5
Molecular Weight:
328.36
MDL number:
MFCD06411568
UNSPSC Code:
12352200
PubChem Substance ID:
24724500
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 34 mg/mL

storage temp.

−20°C

SMILES string

COc1ccc(cc1O)\C=C2\c3ccccc3C(=O)c4ccccc24

InChI

1S/C22H16O3/c1-25-21-11-10-14(13-20(21)23)12-19-15-6-2-4-8-17(15)22(24)18-9-5-3-7-16(18)19/h2-13,23H,1H3

InChI key

MQLACMBJVPINKE-UHFFFAOYSA-N

Biochem/physiol Actions

HMBA is an Inhibitor of microtubule polymerization; apoptosis inducer.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Erwan Dupuis et al.
Talanta, 219, 121345-121345 (2020-09-06)
Capillary electrophoresis (CE) was hyphenated to multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) to determine the model age of a highly enriched uranium (HEU) sample using the 234U/230Th radiochronometer. The use of hydroxymethylbutyric acid (HMBA) as the CE electrolyte was
Yan Wang et al.
Pharmaceutical research, 31(12), 3538-3548 (2014-06-20)
To determine the effect of PEG modification on pharmacologic and gene delivery properties of polymeric CXCR4 antagonist based on Plerixafor. Polymeric Plerixafor (PAMD) was synthesized from Plerixafor (AMD3100) and grafted with different amounts of PEG (2 kDa). CXCR4 antagonism of the
Dong-Hui Xu et al.
International journal of oncology, 45(1), 264-272 (2014-05-03)
Nucleophosmin (NPM, also known as B23), mainly localized in the nucleolus, has been reported to be overexpressed in many types of human cancer, including colon, ovarian, prostate and gastric cancer. NPM was identified while screening the differential nuclear matrix proteins
Olga S Safronova et al.
Nucleic acids research, 42(14), 8954-8969 (2014-07-25)
Hypoxia is associated with a variety of physiological and pathological conditions and elicits specific transcriptional responses. The elongation competence of RNA Polymerase II is regulated by the positive transcription elongation factor b (P-TEFb)-dependent phosphorylation of Ser2 residues on its C-terminal
Ioannis S Vizirianakis et al.
International journal of oncology, 47(1), 303-314 (2015-05-23)
Impairment of ribosome biogenesis contributes to the molecular pathophysiology of ribosomopathies by deregulating cell-lineage specific proliferation, differentiation and apoptosis decisions of haematopoietic progenitor cells. Here, using pro-erythroblast-like murine erythroleukemia (MEL) cells, a model system of erythroid maturation, we aimed to
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