H7039
3-Hydroxy-3-methylglutaryl-CoA reductase human
solution
Synonym(s):
HMGCoA Reductase, HMGR
About This Item
Recommended Products
assay
≥90% (SDS-PAGE)
Quality Level
form
solution
specific activity
2-8 units/mg protein
mol wt
~76 kDa (for the fusion protein)
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... HMGCR(3156)
Application
- in anti-HMGCR enzyme linked immunosorbent assay (ELISA)
- as an antigen to measure anti-HMGCR antibodies by blot analysis
- in HMG-CoA reductase activity assays
- as an antigen to compare in-house antigen via sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)/western blot
Biochem/physiol Actions
Physical properties
Unit Definition
Physical form
inhibitor
substrate
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Articles
Biosynthesis of cholesterol generally takes place in the endoplasmic reticulum of hepatic cells and begins with acetyl- CoA, which is mainly derived from an oxidation reaction in the mitochondria. Acetyl-CoA and acetoacetyl-CoA are converted to 3-hydroxy- 3-methylglutaryl-CoA (HMG-CoA) by HMG-CoA synthase.
Randomized controlled clinical studies have suggested 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are effective in both primary and secondary prevention of cardiovascular disease (CVD) events.
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