Anti-STAT4 antibody produced in rabbit

Signal transducer and activator of transcription 4 (STAT4) belongs to the family of STAT protein, associated with generation of inflammation during protective immune responses. It consists of various active domains for signaling and gene activation, such as a core DNA-binding domain, N-terminal domain essential for STAT4 phosphorylation, SH2 (Src Homology 2) domain and a C-terminal transactivation domain.

Signal transducer and activator of transcription 4 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

STAT4 (signal transducer and activator of transcription 4) is expressed mainly in myeloid cells, developing spermatogonia, and to some lesser extent in thymus and spleen. During myeloid differentiation, its expression as well as activity is regulated by T-cell activation. It has been reported that Jak1 or Jak2 (janus kinase) phosphorylate STAT4 at Tyr693 position and achieves interferons (IFN-γ) activation site-binding activity. Upon activation it moves into the nucleus to initiate gene transcription.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST77484

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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