Anti-ADNP antibody produced in rabbit

ADNP (activity-dependent neuroprotector homeobox) was initially identified as a vasoactive intestinal peptide (VIP) responsive gene in P19 carcinoma cells of mouse. This gene is localized to human chromosome 20q13.13, and is composed of five exons and four introns, and spans 40kb in length. It has a strong homology to hox gene, and contains a homeobox domain and five zinc finger domains.

Activity-dependent neuroprotector recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

ADNP (activity-dependent neuroprotector homeobox) mutations are linked to syndromic autism, which results in hampered social interaction and communication, and behavioral patterns are repetitive and restricted. As this protein is highly homologous to hox protein, it might have a role in embryonic development. It acts as a negative regulator of p53, and thus, has a neuroprotective role. It is involved in the differentiation and maturation of neurons. It interacts with BAF (BRG1-associated factors) complex, which is an ATP-dependent chromatin remodeling complex. However, mutant ADNP is incapable of recruiting and anchoring BAF complex to DNA, thus, hampering several cellular processes. This results in SWI/SNF (SWItch/Sucrose Non-Fermentable)-related ASD (autism spectrum disorders) syndrome, as BAF is homologous to SWI/SNF protein.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST86917

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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