Anti-OPALIN antibody produced in rabbit

Opalin (Oligodendrocytic myelin paranodal and inner loop protein) (Transmembrane protein 10)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

The gene OPALIN (oligodendrocytic myelin paranodal and inner loop protein), also referred to as TMEM10 (transmembrane protein 10), is a type I transmembrane glycoprotein that is abundantly expressed in mature oligodendrocytes of the CNS. It is not expressed in the peripheral nervous system. The protein sequence is highly conserved among mouse, rat and humans. It may serve as a potential marker for assessing myelination as its level is reduced in mouse with hypomyelination. Mouse Opalin contains a short, 1-30 amino acid N-terminal extracellular domain, a transmembrane domain of 31–53 residues, and a long C-terminal intracellular domain with 54–143 residues. The N-terminal 30 amino acid domain is subjected to post-translational modification by N-linked and O-linked oligosaccharides that may be sialylated. Opalin may function in the maturation, maintenance and/or aging of the mammalian central myelin in mouse brain.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST72419

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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