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I134

Sigma-Aldrich

L-N5-(1-Iminoethyl)ornithine hydrochloride

≥95% (HPLC)

Synonym(s):

L-NIO hydrochloride, L-Ornithine ψ-acetamidine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C7H15N3O2 · xHCl
CAS Number:
852173-80-9
Molecular Weight:
173.21 (free base basis)
MDL number:
MFCD00153817
UNSPSC Code:
12352204
PubChem Substance ID:
329815348
NACRES:
NA.26

Quality Level

100

assay

≥95% (HPLC)

form

powder

mol wt

calculated mol wt 173.22 g/mol

storage condition

desiccated
under inert gas

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

CC(NCCC[C@H](N)C(O)=O)=N.[H]Cl

InChI

1S/C7H15N3O2.ClH/c1-5(8)10-4-2-3-6(9)7(11)12;/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12);1H/t6-;/m0./s1

InChI key

JIBZSGQTCBWUKL-RGMNGODLSA-N

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Application

L-N5-(1-Iminoethyl) ornithine hydrochloride has been used to study the effects of the cytotoxic drug paclitaxel and carbachol (a cholinergic agonist) to induce death in breast tumor MCF-7 cells and the role of nitric oxide synthase (NOS) in this effect. It has also been used to study its effects on pulmonary arterial responses to sufentanil in the feline pulmonary vascular bed.

Biochem/physiol Actions

A potent irreversible inhibitor of nitric oxide synthase.

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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International Review of Neurobiology, 42 (1998)
Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase
Alejandro Javier Espa?ol
International Immunopharmacology, 29(1) (2015)
The effects of sufentanil in the feline pulmonary vascular bed
Alan D Kaye
European Journal of Pharmacology (2006)

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