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I7534

Sigma-Aldrich

Monoclonal Anti-Interleukin-1α antibody produced in mouse

clone 4414, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-IL-1α

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About This Item

MDL number:
MFCD01632982
UNSPSC Code:
51111800

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4414, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

capture ELISA: 2-8 μg/mL
immunohistochemistry: 8-25 μg/mL
neutralization: suitable
western blot: 1-2 μg/mL

isotype

IgG2a

UniProt accession no.

P01583

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL1A(3552)

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Immunogen

purified, E. coli-derived recombinant human interleukin-1α (aa 113-271).

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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Axel Weber et al.
Science signaling, 3(105), cm1-cm1 (2010-01-21)
The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes in humans and mice. IL-1-type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1alpha or IL-1beta by
Emmanuel Contassot et al.
Swiss medical weekly, 142, w13590-w13590 (2012-06-02)
Interleukin 1, one of the first cytokines discovered in the 1980s, and a potent mediator of fever, pain and inflammation, is at present experiencing a revival in biology and medicine. Whereas the mechanism of activation and secretion of interleukin 1β
H E Barksby et al.
Clinical and experimental immunology, 149(2), 217-225 (2007-06-26)
Understanding cytokine immunobiology is central to the development of rational therapies for destructive inflammatory diseases such as rheumatoid arthritis (RA) and periodontitis. The classical interleukin-1 (IL-1) family cytokines, IL-1alpha and IL-1beta, as well as IL-18, play key roles in inflammation.

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