I8398
Anti-Interleukin-2 antibody produced in goat
IgG fraction of antiserum, lyophilized powder
Synonym(s):
Anti-IL-2
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About This Item
biological source
goat
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
neutralization: suitable
western blot: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Il2(16183)
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General description
The antibody neutralizes the biological activity of recombinant mouse interleukin-2, but not human interleukin-2.
Immunogen
recombinant mouse interleukin-2 expressed in Escherichia coli.
Biochem/physiol Actions
Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. The effects of IL-2 are mediated by the signaling activated by its binding to IL-2 receptor (IL-2 R). IL-2 activates key signaling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Preparation Note
Purified using protein G.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Ludwig Deml et al.
Infection and immunity, 73(8), 4732-4742 (2005-07-26)
Predominant T-helper 1 (Th1) responses with increased gamma interferon (IFN-gamma) levels have been proposed to play an important role in Helicobacter pylori-induced gastritis and peptic ulceration. However, bacterial factors contributing to the initiation of Th1 polarization of H. pylori-specific immune
B H Nelson et al.
Advances in immunology, 70, 1-81 (1998-10-02)
Studies of the biology of the IL-2 receptor have played a major part in establishing several of the fundamental principles that govern our current understanding of immunology. Chief among these is the contribution made by lymphokines to regulation of the
Arian Laurence et al.
Immunity, 26(3), 371-381 (2007-03-17)
Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17 known as T helper 17 (Th17) cells, which is involved in the pathophysiology of inflammatory diseases and is thought to be developmentally related to regulatory
Linyi Zhang et al.
Cell & bioscience, 4, 51-51 (2014-01-01)
Naturally occurring regulatory T cells (Tregs) play a pivotal role in the maintenance of self-tolerance due to their intrinsic immunosuppressive activity. Currently, a number of human clinical trials are being conducted to investigate the roles of Tregs in treating various
Katrina K Hoyer et al.
Immunological reviews, 226, 19-28 (2009-01-24)
Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T-helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the
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