I9905
Interleukin-2/Fc Chimera (non-lytic) from mouse
>98% (SDS-PAGE), recombinant, expressed in CHO cells, solution
Synonym(s):
IL-2:Fc (non-lytic)
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About This Item
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biological source
mouse
Quality Level
recombinant
expressed in CHO cells
assay
>98% (SDS-PAGE)
form
solution
mol wt
94 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
0.1 mg/mL
impurities
endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Il2(16183)
Biochem/physiol Actions
IL-2 (interleukin-2) is a cytokine which is involved in the differentiation of T cell and natural killer (NK) cell, T cell memory, activation-induced lymphocyte cell death. The protein also has a role in regulatory T cell (Treg) development and homeostasis. It is linked with the risk of Grave′s disease, rheumatoid arthritis, celiac disease, multiple sclerosis, psoriasis, Crohn′s disease, ulcerative colitis and type-1 diabetes (T1D).
Possesses the biological functions of the IL-2 moiety and a prolonged circulating half-life determined by the Fc domain.
Other Notes
Dimeric fusion protein consisting of mouse IL-2 fused to mutant mouse IgG2a Fc.
Physical form
Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.
Analysis Note
The biological activity is measured in a cell proliferation assay using CTLL2 cells.
Certificates of Analysis (COA)
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R J Robb et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(20), 6486-6490 (1984-10-01)
Human interleukin 2 was separated into multiple molecular forms by selective immunoaffinity chromatography and chromatofocusing. For the most part, this heterogeneity was attributed to variations in glycosylation of the threonine residue in position 3 of the polypeptide chain. The various
Parul Mehra et al.
Molecular and cellular biology, 35(22), 3880-3891 (2015-09-10)
Interleukin-2 (IL-2) is a potent cytokine with roles in both immunity and tolerance. Genetic studies in humans and mice demonstrate a role for Il2 in autoimmune disease susceptibility, and for decades the proximal Il2 upstream regulatory region has served as
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