L2420
Monoclonal Anti-LRP1 antibody produced in mouse
~1.0 mg/mL, clone LRP1-11, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-A2MR, Anti-APOER, Anti-APR, Anti-Apolipoprotein E receptor, Anti-Apolipoprotein receptor, Anti-CD91, Anti-LRP, Anti-Lipoprotein receptor-related protein, Anti-Low density lipoprotein receptor-related protein 1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
LRP1-11, monoclonal
form
buffered aqueous solution
mol wt
antigen ~500 kDa
species reactivity
human, rat, mouse
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: suitable
western blot: 1-2 μg/mL
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LRP1(4035)
mouse ... Lrp1(16971) , Lrp1(299858)
General description
Monoclonal Anti-LRP1 (mouse IgG1 isotype) is derived from the hybridoma LRP1-11 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human LRP1, conjugated to KLH. LDL receptor family. Low-density lipoprotein (LDL) receptor related protein 1 (LRP1) gene is mapped to human chromosome 12q13.3. LRP1 protein, belongs to the LDL receptor family. LRP1, a single-chain 600 kDa type I transmembrane glycosylated precursor protein, is produced in the endoplasmic reticulum. This protein is proteolytically cleaved in the Golgi complex into two subunits including 85-kDa membrane-bound C-terminal membrane spanning subunit and a noncovalently attached 515-kDa N-terminal subunit.
Specificity
Monoclonal Anti-LRP1 recognizes human, rat, and mouse LRP1.
Application
Monoclonal Anti-LRP1 antibody produced in mouse has been used in:
- immunoblotting
- enzyme linked immunosorbent assay
- immunofluorescence
Biochem/physiol Actions
Low density lipoprotein receptor related protein 1 (LRP1) plays an essential role in early stages of embryonic development. It aids in lipoprotein metabolism, proteinase regulation, activation of lysosomal enzymes and cellular entry of viruses and toxins. Additionally, It is also implicated in cell signaling pathways, cell migration, and neurodevelopment. LRP1 interacts with at least 30 different ligands including lipoproteins, proteinases, proteinase-inhibitor complexes, extra cellular matrix (ECM) proteins and various intracellular proteins. Furthermore, LDL receptor related protein 1 also has an ability to associate with bacterial toxins and viruses.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discard if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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