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L8643

Sigma-Aldrich

Lipopolysaccharides from Pseudomonas aeruginosa 10

purified by gel-filtration chromatography

Synonym(s):

LPS

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About This Item

MDL number:
MFCD00131520
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

Pseudomonas aeruginosa (10)

Quality Level

200

form

lyophilized powder

purified by

gel-filtration chromatography

impurities

<3% Protein (Lowry)

color

white to faint yellow

solubility

water: 4.90-5.10 mg/mL, cloudy to hazy, colorless to faintly yellow

storage temp.

2-8°C

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Application

Lipopolysaccharides from Pseudomonas aeruginosa 10 has been used as an inflammatory mediator in cells.
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Other Notes

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha.
Russell JP
Infection and Immunity, 64, 1565-1565 (1996)
Clara cells attenuate the inflammatory response through regulation of macrophage behavior.
Snyder JC
American Journal of Respiratory Cell and Molecular Biology, 42, 161-171 (2010)
Sandra Chang et al.
PloS one, 10(7), e0131810-e0131810 (2015-07-07)
Oxidant production from DUOX1 has been proposed to lead to neutrophil recruitment into the airways when lung homeostasis is compromised. The objective of this study was to determine whether DUOX-derived hydrogen peroxide is required for LPS-induced neutrophil recruitment, using a
Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice.
Bruscia EM
American Journal of Respiratory Cell and Molecular Biology, 40, 295-295 (2009)
Austin Boucher et al.
Journal of immunology (Baltimore, Md. : 1950), 206(3), 540-553 (2020-12-18)
Macrophages are critical for regulating inflammatory responses. Environmental signals polarize macrophages to either a proinflammatory (M1) state or an anti-inflammatory (M2) state. We observed that the microRNA (miRNA) cluster mirn23a, coding for miRs-23a, -27a, and -24-2, regulates mouse macrophage polarization.
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