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M076000

Sigma-Aldrich

Sulfur 42

Synonym(s):

Phenyl-3H-1,2,4-dithiazol-3-one

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About This Item

Empirical Formula (Hill Notation):
C8H5NOS2
CAS Number:
Molecular Weight:
195.26
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.03

type

for DNA synthesis

Quality Level

product line

Proligo Reagents

assay

≥99.0% (reversed phase HPLC)

form

solid

packaging

pkg of 1 g M076000-1G
2 g of 2 g M076000-2G

impurities

≤0.1% water content (Karl Fischer)

color

faintly yellow to yellow

solubility

acetonitrile: 0.1 M, clear

suitability

conforms to structure for H-NMR

storage temp.

2-8°C

SMILES string

O=C1SSC(C2=CC=CC=C2)=N1

InChI

1S/C8H5NOS2/c10-8-9-7(11-12-8)6-4-2-1-3-5-6/h1-5H

InChI key

LKDWQHQNDDNHSC-UHFFFAOYSA-N

Related Categories

General description

Sulfur 42 is a sulfurization reagent.

Application

Sulfur 42 is suitable for use instead of an Oxidizer during the synthesis cycle to manufacture thioated oligonucleotides.

Features and Benefits

  • Sulfur 42 is at least 4 times more reactive than Beaucage reagent or PADS
  • Crystalline powder
  • Odourless, no foul smell
  • Solubility in ACN up to 0.28M at (+10 °C); no need to applied a co-solvent like in DCM, THF
  • The solvent for the dissolution of the reagent should be dry (< 50 ppm) in order to minimize P=O impurities
  • Stable in ACN solution for at least 21 days
  • Recommended reaction time for the sulfurization in oligonucleotide synthesis for a 0.1M solution is 60 sec

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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