M0939
Anti-α-MSH antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-α-Melanocyte Stimulating Hormone
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 1664.9 kDa
species reactivity
human
technique(s)
ELISA: 1:4,000
microarray: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... POMC(5443)
Related Categories
General description
Pro-opiomelanocortin (POMC), a complex pro-peptide is expressed in hypothalamus, pituitary gland, skin and the immune system. This gene is located on human chromosome 2p23.3.
Immunogen
synthetic α-MSH peptide conjugated to bovine serum albumin.
Application
Anti-α-MSH antibody produced in rabbit has been used in:
- immunohistochemistry
- radioimmunoassay/α-MSH immunoassay
- enzyme linked immunosorbent assay (ELISA)
Biochem/physiol Actions
α-MSH (melanocyte stimulating hormone) and melanocortin-4-receptor (MC4R) are key signaling components in the control of energy homeostasis and of the hypothalamic response to obesity. Mutations that reduce the functional activity of -MSH lead to obesity in mammals and mice lacking the MC4 receptor (MC4R-/-) are hyperphagic and very obese, indicating that -MSH signaling transduced by MC4-R limits food intake and body fat mass.
α-Melanocyte Stimulating Hormone (α-MSH) stimulates the production of melanin in melanocytes and induced pigmentation and skin darkening. It increases the activity of tyrosinase that induces melanogenesis. α-MSH has potent anti-inflammatory effects and is also a neuromodulator. Analogs of α-MSH may be used to study melanogenesis and neuromodulation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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N Rajora et al.
Journal of leukocyte biology, 59(2), 248-253 (1996-02-01)
alpha-Melanocyte-stimulating hormone (alpha-MSH), a tridecapeptide derived from pro-opiomelanocortin, has potent antiinflammatory activity in laboratory animals. alpha-MSH inhibits nitric oxide production by murine macrophages, an influence believed to reflect activation of an autocrine circuit in these cells, one that is based
Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector
Siu JJ, et al.
Molecular therapy. Methods & clinical development, 7, 83-95 (2017)
alpha-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors
Enriori PJ, et al.
Molecular Metabolism, 5(10), 807-822 (2016)
Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells
Stout GJ and Blasco MA
Disease models & mechanisms, 2(3-4), 139-156 (2009)
G Hunt et al.
Journal of cell science, 107 ( Pt 1), 205-211 (1994-01-01)
Although melanocyte stimulating hormone (MSH) peptides are known to stimulate pigmentation in man, previous reports suggest that human melanocytes are relatively unresponsive to these peptides in vitro. This may be related to the conditions under which the melanocytes were cultured.
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