Skip to Content
MilliporeSigma
All Photos(2)

Documents

M3281

Sigma-Aldrich

α-Methyl-DL-tyrosine methyl ester hydrochloride

≥95% (HPLC)

Synonym(s):

α-MT methyl ester hydrochloride, 2-Methyl-4-hydroxy-DL-phenylalanine methyl ester hydrochloride, AMPT methyl ester hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Linear Formula:
4-(HO)C6H4CH2C(CH3)(NH2)CO2CH3 · HCl
CAS Number:
7361-31-1
Molecular Weight:
245.70
Beilstein/REAXYS Number:
5163031
EC Number:
230-900-0
MDL number:
MFCD00012606
UNSPSC Code:
12352108
PubChem Substance ID:
24278548
NACRES:
NA.32

Quality Level

100

assay

≥95% (HPLC)

mp

192 °C (dec.) (lit.)

solubility

DMSO: ≥20 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cl[H].COC(=O)C(C)(N)Cc1ccc(O)cc1

InChI

1S/C11H15NO3.ClH/c1-11(12,10(14)15-2)7-8-3-5-9(13)6-4-8;/h3-6,13H,7,12H2,1-2H3;1H

InChI key

OOVDEPZODSXAMU-UHFFFAOYSA-N

Gene Information

human ... TH(7054)

Looking for similar products? Visit Product Comparison Guide

Application

α-Methyl-DL-tyrosine methyl ester hydrochloride has been used to evaluate norepinephrine turnover.

Biochem/physiol Actions

α-Methyl-DL-tyrosine (α-MT) prevents hyperactivity, sniffing-licking-gnawing syndrome, anorexia and ameliorates certain effects of amphetamine. It inhibits dopamine production and prevents apoptosis stimulated by mutant α-synuclein.
Tyrosine hydroxylase inhibitor.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 2

1 of 2

3-Iodo-L-tyrosine

Sigma-Aldrich

I8250

3-Iodo-L-tyrosine

Reserpine

Sigma-Aldrich

R0875

Reserpine

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease
Xu J, et al.
Nature Medicine, 8(6), 600-600 (2002)
Central sympathetic innervations to visceral and subcutaneous white adipose tissue
Nguyen, Ngoc Ly T and Randall, Jessica and Banfield, Bruce W and Bartness, Timoth NLT, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 306(6), R375-R386 (2014)
Antiamphetamine effects following inhibition of tyrosine hydroxylase
Weissman A
Journal of Pharmacology and Experimental Therapeutics, 151(3), 339-352 (1966)
Johan P Rung et al.
Naunyn-Schmiedeberg's archives of pharmacology, 384(1), 39-45 (2011-05-03)
Dopaminergic stabilizers may be conceptualized as drugs with normalizing effects on dopamine-mediated behaviours and neurochemical events. (S)-(-)-OSU6162 (OSU6162) and ACR16 are two structurally related compounds ascribed such properties, principally because of their stabilizing effects on motor activity in rodents. Reports
C Miguelez et al.
Neuropharmacology, 56(6-7), 1068-1073 (2009-03-21)
So far, the mechanisms underlying the action of selective serotonin reuptake inhibitors, such as fluoxetine, are not completely understood. Thus, to clarify if fluoxetine has any effect on noradrenergic transmission, we measured the spontaneous firing rate of noradrenergic neurons in
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service