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M8631

Sigma-Aldrich

Melanin

Synthetic

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About This Item

CAS Number:
8049-97-6
EC Number:
232-473-6
MDL number:
MFCD00131581
UNSPSC Code:
12352204
NACRES:
NA.83

Quality Level

100

form

powder

storage temp.

−20°C

InChI

1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3

InChI key

XUMBMVFBXHLACL-UHFFFAOYSA-N

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General description

Melanin is a vital pigment present on the surface structures of vertebrates, which contribute to skin color. It has three forms such as, eumelanin, pheomelanin and neuromelanin. Melanin has cation chelating and redox properties. It is a potent absorbent of light. Melanin functions as a chemoprotective and photoprotective pigment. Mutations in this gene are associated with oculocutaneous albinism, vitiligo, piebaldism and Waardenburg syndrome.

Application

Melanin has been used:
  • in spectrophotometry
  • to study its effect on reverse transcription polymerase chain reaction (RT-PCR) inhibition and effect of BSA (bovine serum albumin) in overcoming the inhibition
  • as an absorber for skin layer in near-infrared tissue spectra
  • Raman spectroscopy

Preparation Note

Prepared by oxidation of tyrosine with hydrogen peroxide.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Removal of analyte-irrelevant variations in near-infrared tissue spectra
Yang Y, et al.
Applied Spectroscopy, 60(9), 1070-1077 (2006)
Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes
Yoshino M, et al.
International Immunology, 18(11), 1541-1548 (2006)
Diorders of Pigmentation
Zaidi Z, et al.
Treatment of Skin Diseases, 159-170 (2019)
Miguel J Beltrán-García et al.
PloS one, 9(3), e91616-e91616 (2014-03-22)
In pathogenic fungi, melanin contributes to virulence, allowing tissue invasion and inactivation of the plant defence system, but has never been implicated as a factor for host cell death, or as a light-activated phytotoxin. Our research shows that melanin synthesized
Melanin
Riley PA
The International Journal of Biochemistry & Cell Biology, 29(11), 1235-1239 (1997)
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