MAK305
CETP RP Activity Assay
(Supplied by Roar Biomedical, Inc.)
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.84
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usage
sufficient for 100 fluorometric tests
application(s)
pharmaceutical
detection method
fluorometric
relevant disease(s)
cardiovascular diseases
storage temp.
2-8°C
Related Categories
General description
Cholesteryl ester transfer protein (CETP) is present in normal human plasma and transfers neutral lipids from high density lipoproteins (HDL) to very low density lipoprotein (VLDL) and low density lipoprotein (LDL). CETP plays an important role in lipoprotein metabolism and influences the reverse cholesterol transport pathway.
Features and Benefits
Synthetic assay components support manipulation for MOA studies and SAR work. Unusually high signal-to-background with linearity. Assay components stable for up to 1 year. High DMSO tolerance.
Suitability
Suitable for high-throughput screening (HTS), mechanism of action (MOA) studies, and structure-activity relationship (SAR) work in CETP sources.
Principle
The CETP RP Activity Assay uses a proprietary substrate that enables the detection of CETP-mediated neutral lipid mass transfer. The method is useful for measuring CETP activity in recombinant protein (RP) or purified CETP samples and has a high DMSO tolerance. The transfer activity results in an increase in fluorescence intensity (λEx = 465 nm/λEm = 535 nm). With recombinant CETP as the CETP source, the assay is linear over a wide range of CETP concentrations and provides very high signal-to-background values. Typical Z factor: ∼0.9
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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