Skip to Content
MilliporeSigma
All Photos(1)

Documents

N1915

Sigma-Aldrich

Nebivolol hydrochloride

≥98% (HPLC)

Synonym(s):

Narbivolol, Nebilet, R-65824, rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C22H25F2NO4 · HCl
CAS Number:
152520-56-4
Molecular Weight:
441.90
UNSPSC Code:
12352200
PubChem Substance ID:
329818593
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: ≥20 mg/mL

originator

Forest Labs

storage temp.

room temp

SMILES string

Cl.O[C@@H](CNC[C@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]3CCc4cc(F)ccc4O3

InChI

1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/m0./s1

InChI key

JWEXHQAEWHKGCW-BIISKSHESA-N

Looking for similar products? Visit Product Comparison Guide

Application

Nebivolol hydrochloride has been used as a standard in the validation of high-performance thin-layer chromatography (HPTLC)-densitometry method. It may be used in calibration curve preparation and absorption spectrum studies using spectrophotometry.

Biochem/physiol Actions

Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies. It stabilizes membrane and possesses intrinsic sympathomimetic functionality. Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods.
Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension. It is 40-fold selective for β1 vs. β2, and lacks ISA (intrinsic sympathomimetic activity).

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 9

1 of 9

(±)-Metoprolol (+)-tartrate salt ≥98% (titration), powder

Sigma-Aldrich

M5391

(±)-Metoprolol (+)-tartrate salt

ICI 118,551 hydrochloride ≥98% (HPLC), powder

Sigma-Aldrich

I127

ICI 118,551 hydrochloride

Lercanidipine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

L6668

Lercanidipine hydrochloride

CGP-20712A methanesulfonate salt solid, ≥98% (HPLC)

Sigma-Aldrich

C231

CGP-20712A methanesulfonate salt

Carvedilol European Pharmacopoeia (EP) Reference Standard

Y0001427

Carvedilol

Doxazosin mesylate ≥97% (HPLC), powder

Sigma-Aldrich

D9815

Doxazosin mesylate

Betaxolol hydrochloride >98% (HPLC)

Sigma-Aldrich

B5683

Betaxolol hydrochloride

Metoprolol tartrate European Pharmacopoeia (EP) Reference Standard

M1830000

Metoprolol tartrate

(S)-(−)-Propranolol hydrochloride ≥98% (TLC), powder

Sigma-Aldrich

P8688

(S)-(−)-Propranolol hydrochloride

Vijay Singh Jatav et al.
Advanced biomedical research, 2, 62-62 (2013-11-14)
Nebivolol hydrochloride is a third generation β-blocker with highly selective β1-receptor antagonist with antihypertensive properties having plasma half life of 10 h and 12% oral bioavailability. The aim of the present investigation was to form matrix type transdermal patches containing
New spectrophotometric determination of nebivolol in pharmaceutical formulation via charge transfer complex
Alhemiary, Nabil AF
Austin Journal of Analytical and Pharmaceutical Chemistry , 4(2), 1084-1091 (2017)
Deepak Sharma et al.
Pharmaceutical methods, 2(1), 9-14 (2011-01-01)
The present study aimed to develop and validate the simultaneous estimation of amlodipine and nebivolol in tablet dosage forms. An isocratic reversed phase high-performance liquid chromatographic (HPLC) method with ultraviolet detection at 268 nm has been developed for the determination
Development of quantitative HPTLC-Densitometry methods for the analysis of amiodarone HCl, carvedilol, doxylamine succinate, magnesium salicylate, metoprolol succinate, nebivolol HCl, and salicylamide using a model process developed earlier for the transfer of TLC screening methods
Nguyen K and Sherma J
Acta Chromatographica , 30(4), 264-268 (2018)
Jillian G Baker et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(12), 4486-4497 (2011-08-26)
β-Adrenoceptor antagonists differ in their degree of partial agonism. In vitro assays have provided information on ligand affinity, selectivity, and intrinsic efficacy. However, the extent to which these properties are manifest in vivo is less clear. Conscious freely moving rats
View All Related Papers

Articles

β-Adrenoceptors

β-Adrenoceptors are activated either by norepinephrine or epinephrine. Learn more about the role of β-adrenoceptors in protein expression, cell signaling, and metabolism research.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service