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N7537

Sigma-Aldrich

NSC 663284

≥98% (HPLC), solid

Synonym(s):

6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione

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About This Item

Empirical Formula (Hill Notation):
C15H16ClN3O3
CAS Number:
383907-43-5
Molecular Weight:
321.76
MDL number:
MFCD08276924
UNSPSC Code:
12352200
PubChem Substance ID:
24724556
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

red

solubility

DMSO: ≥10 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O

InChI

1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2

InChI key

BMKPVDQDJQWBPD-UHFFFAOYSA-N

Gene Information

human ... CDC25B(994) , DUSP3(1845) , PTPN1(5770)

Application

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Biochem/physiol Actions

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.
Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

470.1 °F

flash_point_c

243.4 °C

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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