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O0141

Sigma-Aldrich

Obestatin human

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About This Item

Empirical Formula (Hill Notation):
C116H176N32O33
CAS Number:
1081110-72-6
Molecular Weight:
2546.83
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

synthetic

Quality Level

200

sterility

non-sterile

assay

≥97% (HPLC)

form

lyophilized powder

color

white

solubility

deionized water: 1 mg/mL

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C116H176N32O33/c1-13-61(10)95(146-91(158)53-127-113(178)93(59(6)7)147-110(175)81(50-92(159)160)141-108(173)78(46-65-25-18-15-19-26-65)142-112(177)84-28-22-42-148(84)116(181)63(12)130-105(170)80(49-89(123)156)137-98(163)69(118)45-64-23-16-14-17-24-64)115(180)134-70(27-20-21-41-117)101(166)138-76(44-58(4)5)106(171)143-82(54-149)99(164)126-52-90(157)145-94(60(8)9)114(179)135-74(36-40-88(122)155)104(169)139-77(47-66-29-31-68(151)32-30-66)107(172)132-72(34-38-86(120)153)102(167)131-73(35-39-87(121)154)103(168)140-79(48-67-51-125-56-128-67)109(174)144-83(55-150)111(176)133-71(33-37-85(119)152)100(165)129-62(11)97(162)136-75(96(124)161)43-57(2)3/h14-19,23-26,29-32,51,56-63,69-84,93-95,149-151H,13,20-22,27-28,33-50,52-55,117-118H2,1-12H3,(H2,119,152)(H2,120,153)(H2,121,154)(H2,122,155)(H2,123,156)(H2,124,161)(H,125,128)(H,126,164)(H,127,178)(H,129,165)(H,130,170)(H,131,167)(H,132,172)(H,133,176)(H,134,180)(H,135,179)(H,136,162)(H,137,163)(H,138,166)(H,139,169)(H,140,168)(H,141,173)(H,142,177)(H,143,171)(H,144,174)(H,145,157)(H,146,158)(H,147,175)(H,159,160)/t61-,62-,63-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,93-,94-,95-/m0/s1

InChI key

IXQOGPZNKNSCJR-QQDMDDJXSA-N

Gene Information

human ... GHRL(51738)

Amino Acid Sequence

Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Val-Gln-Tyr-Gln-Gln-His-Ser-Gln-Ala-Leu-NH2

General description

Obestatin is a 23-amino acid peptide. It is encoded by the ghrelin gene.

Application

Human obestatin has been used to study its role in differentiation in rat preadipocytes.

Biochem/physiol Actions

It does not participate in the release of growth hormone.
Obestatin, an obesity peptide, along with Ghrelin peptides are derived from the same prepropeptide, Ghrelin. In contrast to Ghrelin, Obestatin suppresses food intake, body weight gain, and gastrointestinal motility in rodents.

Physical form

Lyophilized from 0.1% aqueous trifluoroacetate (TFA).

Other Notes

Lyophilized from 0.1% TFA in H2O

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Obestatin stimulates differentiation and regulates lipolysis and leptin secretion in rat preadipocytes
Tatiana Wojciechowicz
Molecular Medicine Reports (2015)

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