O7889
Anti-OMP antibody produced in rabbit
~2 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Olfactory Marker Protein
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~19 kDa
species reactivity
rat, mouse
concentration
~2 mg/mL
technique(s)
western blot: 0.5-1.0 μg/mL using rat brain (olfactory bulb) extract (S1 fraction).
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Omp(24612)
General description
Olfactory marker protein (OMP) is a phylogenetically conserved cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons, in essentially all vertebrate species. OMP is expressed in both the olfactory neuroepithelium and the olfactory nerve projection to the olfactory bulb. In perikaryon, OMP is produced and are transported to the dendrite and axon in the glomerular layer of the olfactory bulb.
Olfactory marker protein (OMP) is a phylogenetically conserved, 19kDa, cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons, in essentially all vertebrate species. The gene encoding OMP is localized on rat chromosome 1. OMP expression is initially detected in rat and mouse embryo during the last trimester of gestation and reaches adult levels at 2-4 weeks postnatally. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.
Immunogen
synthetic peptide corresponding to amino acids 119-137 located near the C-terminus of rat OMP conjugated to KLH.
Application
Anti-OMP antibody produced in rabbit has been used in immunohistochemistry.
Anti-OMP antibody produced in rabbit has been used in:
- immunoblotting
- double immunofluorescence
- staining
Biochem/physiol Actions
Olfactory marker protein (OMP) helps to modulate the formation and refinement of the olfactory glomerular map. OMP-deficient mice generated by gene targeting in embryonic stem (ES) cells are compromised in their ability to respond to odor stimuli. In the OMP-null mouse, in addition to reduced odorant response, the levels of neural tyrosine hydroxylase (TH) and neuropeptide cholecystokinin (CCK) are severely reduced. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Expression of CD36 by olfactory receptor cells and its abundance on the epithelial surface in mice
Lee S, et al.
PLoS ONE, 10(7), e0133412-e0133412 (2015)
Diverse populations of intrinsic cholinergic interneurons in the mouse olfactory bulb
Kurt K
Neuroscience, 161-178 (2012)
Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons
Buiakova OI, et al.
Proceedings of the National Academy of Sciences of the USA, 93(18), 9858-9863 (1996)
Backbone dynamics of the olfactory marker protein as studied by 15N NMR relaxation measurements.
Biochemistry, 44(28), 9673-9679 (2005)
Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons.
Proceedings of the National Academy of Sciences of the USA, 93(18), 9858-9863 (1996)
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