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P0618

Sigma-Aldrich

cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide

≥98% (HPLC), solid

Synonym(s):

cis(±)-8-OH-PBZI hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C15H21NO · HBr
Molecular Weight:
312.25
MDL number:
MFCD11045999
UNSPSC Code:
12352202
PubChem Substance ID:
24278794
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

light brown

solubility

H2O: soluble ~10 mg/mL at 60 °C (Sonicate)
DMSO: soluble 12 mg/mL

storage temp.

2-8°C

SMILES string

Br.CCCN1CC[C@@H]2[C@H]1CCc3ccc(O)cc23

InChI

1S/C15H21NO.BrH/c1-2-8-16-9-7-13-14-10-12(17)5-3-11(14)4-6-15(13)16;/h3,5,10,13,15,17H,2,4,6-9H2,1H3;1H/t13-,15+;/m0./s1

InChI key

UMGQLEXNQCHIFN-NQQJLSKUSA-N

Gene Information

human ... DRD3(1814)

Biochem/physiol Actions

D3 dopamine receptor agonist.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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E V Kuzhikandathil et al.
Pharmaceutical research, 29(8), 2264-2275 (2012-05-02)
The D3 dopamine receptor exhibits tolerance and slow response termination (SRT) properties that are not exhibited by the closely-related D2 dopamine receptor. We previously demonstrated that the induction of tolerance elicits a unique conformational change in the D3 receptor. Here
Ligia Westrich et al.
Biochemical pharmacology, 79(6), 897-907 (2009-11-03)
The D3 but not D2 dopamine receptors exhibit a tolerance property in which agonist-induced D3 receptor response progressively decreases upon repeated agonist stimulation. We have previously shown that the D3 receptor tolerance property is not mediated by receptor internalization, persistent

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