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P1495

Sigma-Aldrich

Anti-Phosphatidylserine Receptor antibody produced in rabbit

1-1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-PSR

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About This Item

MDL number:
MFCD04040521
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 50-70 kDa

species reactivity

mouse, human

concentration

1-1.5 mg/mL

technique(s)

immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:1,000 using whole extracts of human HeLa or A549 cells
western blot: 1:500 using whole extracts of mouse NIH3T3 cells

UniProt accession no.

Q6NYC1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... JMJD6(23210)
mouse ... Jmjd6(107817)

General description

Phosphatidylserine Receptor (PSR) is an evolutionarily conserved glycoprotein that is widely expressed in cells and tissues. It is very susceptible to cleavage by protease or elastase. PSR engagement plays an important role in macro-pinocytosis and uptake of tethered apoptotic cells. Cooperation with other receptors and their ligands may also be needed for ingestion of apoptotic cells. PSR is involved in suppression of inflammatory and immune responses.
Phosphatidylserine receptor belongs to the group of Jumonji domain containing protein 6 (JMJD6). It is known to be localized to the phagocytes. PSR is an evolutionarily conserved glycoprotein that is widely expressed in cells and tissues.

Specificity

Anti-Phosphatidylserine Receptor (PSR) recognizes human and mouse phosphatidylserine receptor (PSR). Detection of the phosphatidylserine receptor by immunoblotting is specifically inhibited by the immunizing peptide, a synthetic peptide corresponding to amino acid residues 363-381 of the human phosphatidylserine receptor, conjugated to maleimide-activated KLH as immunogen.

Immunogen

synthetic peptide corresponding to amino acid residues 363-381 of the human phosphatidylserine receptor conjugated to maleimide-activated KLH. The corresponding sequence in mouse differs by one amino acid.

Application

Anti-Phosphatidylserine Receptor antibody is sutiable for use in immunoprecipitation and immunoblotting (~50-70 kDa) applications.

Biochem/physiol Actions

Phosphatidylserine receptor (PSR) is very susceptible to cleavage by protease or elastase. PSR engagement plays an important role in macro-pinocytosis and uptake of tethered apoptotic cells. Cooperation with other receptors and their ligands may also be needed for ingestion of apoptotic cells. PSR is involved in suppression of inflammatory and immune responses.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mm sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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flash_point_c

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Certificates of Analysis (COA)

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JMJD6 promotes hepatocellular carcinoma carcinogenesis by targeting CDK4
Wan J, et al.
International Journal of Cancer. Journal International Du Cancer, 144(10), 2489-2500 (2019)
Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases
Fadok VA, et al.
Journal of immunology (Baltimore, Md. : 1950), 166(11), 6847-6854 (2001)
Phosphatidylserine, a death knell
Schlegel RA and Williamson P
Cell Death and Differentiation, 8(6), 551-551 (2001)
Eva Pallinger et al.
Scientific reports, 8(1), 4662-4662 (2018-03-20)
Earlier evidence suggests, that the embryo signals to the maternal immune system. Extracellular vesicles (EVs) are produced by all types of cells, and because they transport different kinds of molecules from one cell to the other, they can be considered

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