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P5372

Sigma-Aldrich

Anti-Potassium Channel Kv7.1 (KCNQ1) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-KVLQT1, Anti-Voltage-gated potassium channel QKT subfamily member 1

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About This Item

MDL number:
MFCD06798517
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat, human

technique(s)

western blot: 1:200 using rat heart membranes

UniProt accession no.

P51787

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCNQ1(3784)
mouse ... Kcnq1(16535)
rat ... Kcnq1(84020)

Specificity

Does not cross react with other QKT proteins.

Immunogen

synthetic peptide corresponding to amino acid residues 661-676 of human KCNQ1. This sequence has 14/16 residues identical in rat and mouse.

Target description

Potassium Channel Kv7.1 (KCNQ1) encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins,

Physical form

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.025% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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flash_point_c

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Certificates of Analysis (COA)

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Christian A Hübner et al.
Human molecular genetics, 11(20), 2435-2445 (2002-09-28)
Ion channels serve many functions apart from electrical signal transduction: chemical signalling (Ca(2+) as a second messenger), transepithelial transport, regulation of cytoplasmic or vesicular ion concentration and pH, and regulation of cell volume. Therefore, ion channel dysfunction can cause diseases
Kazuya Yamagata et al.
Biochemical and biophysical research communications, 407(3), 620-625 (2011-03-24)
KCNQ1, located on 11p15.5, encodes a voltage-gated K(+) channel with six transmembrane regions, and loss-of-function mutations in the KCNQ1 gene cause hereditary long QT syndrome. Recent genetic studies have identified that single nucleotide polymorphisms located in intron 15 of the
J Robbins
Pharmacology & therapeutics, 90(1), 1-19 (2001-07-13)
KCNQ genes encode a growing family of six transmembrane domains, single pore-loop, K(+) channel alpha-subunits that have a wide range of physiological correlates. KCNQ1 (KvLTQ1) is co-assembled with the product of the KCNE1 (minimal K(+)-channel protein) gene in the heart

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