Skip to Content
MilliporeSigma
All Photos(1)

Documents

P7527

Sigma-Aldrich

Prostaglandin E1

powder, γ-irradiated, BioXtra, suitable for cell culture

Synonym(s):

(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE1

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C20H34O5
CAS Number:
745-65-3
Molecular Weight:
354.48
Beilstein/REAXYS Number:
5294062
EC Number:
212-017-2
MDL number:
MFCD00077860
UNSPSC Code:
12352209
PubChem Substance ID:
24898855
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

sterility

γ-irradiated

product line

BioXtra

form

powder

concentration

≥60% (HPLC)

technique(s)

cell culture | mammalian: suitable

solubility

ethanol: 1 mg/mL

storage temp.

−20°C

SMILES string

O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1

InChI

1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

InChI key

GMVPRGQOIOIIMI-DWKJAMRDSA-N

Gene Information

human ... PTGER1(5731) , PTGER2(5732) , PTGIR(5739)
mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

For use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.
Prostaglandin E1 has been used in maintaining mice proximal tubule, and NRK-52E, a rat renal epithelial cell line.

Biochem/physiol Actions

Prostaglandins mediate vasodilation and vasoconstriction, the E series of prostaglandin is a highly effective vasodilator. It is known to efficiently cause erythema. Prostaglandin E1 is considered as a potent pyretic factor, and acts through cerebral ventricles. Prostaglandin E1 is useful to prolong cardiovascular function in new born suffering from ductus-dependant congenital heart disease until surgery.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 9

1 of 9

Prostaglandin I2 sodium salt ≥96% (HPLC), synthetic, powder

Sigma-Aldrich

P6188

Prostaglandin I2 sodium salt

Sigma-Aldrich

Sigma-Aldrich

C3821

Citrate-dextrose solution (ACD)

Sigma-Aldrich

Sigma-Aldrich

SRP3196

EGF from mouse

3,3′,5-Triiodo-L-thyronine (T3) solution 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

T-074

3,3′,5-Triiodo-L-thyronine (T3) solution

3,3′,5-Triiodo-L-thyronine sodium salt γ-irradiated, powder, suitable for, suitable for cell culture

Sigma-Aldrich

T5516

3,3′,5-Triiodo-L-thyronine sodium salt

Sigma-Aldrich

Sigma-Aldrich

A6410

Apyrase from potatoes

Hydrocortisone BioReagent, suitable for cell culture

Sigma-Aldrich

H0888

Hydrocortisone

Sigma-Aldrich

Sigma-Aldrich

T2397

Tyrode′s Salts

Hydrocortisone γ-irradiated, powder, BioXtra, suitable for cell culture

Sigma-Aldrich

H0135

Hydrocortisone

Long-term prostaglandin E1 infusion for newborns with critical congenital heart disease
Aykanat A, et al.
Pediatric Cardiology, 37(1), 131-134 (2016)
Naturally produced crystals obtained from kidney stones are less injurious to renal tubular epithelial cells than synthetic crystals
Escobar C, et al.
BJU International, 100(4), 891-897 (2007)
The Prostaglandins (2013)
Stephen A Davis et al.
Nature chemical biology, 11(7), 481-487 (2015-06-02)
Drugs that act more promiscuously provide fewer routes for the emergence of resistant mutants. This benefit, however, often comes at the cost of serious off-target and dose-limiting toxicities. The classic example is the antifungal amphotericin B (AmB), which has evaded
Mark S Szczypka et al.
Stem cells (Dayton, Ohio), 23(1), 44-54 (2004-12-31)
Results obtained in recent experiments suggest that bone marrow-derived cells (BMDCs) engraft into tissues and differentiate into various somatic cell types. However, it is unclear whether injury is required for the phenomenon to occur at appreciable frequencies. In this study
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service