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P9389

Sigma-Aldrich

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt

double stranded, alternating copolymer

Synonym(s):

Poly(dG-dC) • Poly(dG-dC)

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
41106305
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

form

powder or solid

storage temp.

−20°C

General description

Poly(deoxyguanylic-deoxycytidylic) acid (poly(dG-dC)) undergoes salt dependent conformational transition. Under high-salt, it exists as a left-handed double helix and at low-salt it displays B-DNA conformation. However on immobilization, poly(dG-dC) takes up A DNA form.

Application

Poly(deoxyguanylic-deoxycytidylic) acid (Poly(dG-dC) • Poly(dG-dC)) is an alternating copolymer, self-complementary, double-stranded DNA model for conformational studies of DNA structure dynamics and drug interaction.
Poly(deoxyguanylic-deoxycytidylic) acid sodium salt has been used:
  • in electrophoretic mobility shift assay of transcription factor IIIB complex
  • as synthetic copolymers for circular dichroism (CD) spectroscopy studies
  • as a positive control in liquid scintillation counting

Other Notes

Alternating copolymer; self-complementary, form double-stranded complex

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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American Journal of Clinical Nutrition, 72(4), 998-1003 (2000)
Salt-dependent dynamic structure of poly (dG-dC) textperiodcentered poly (dG-dC)
Ramstein J and Leng M
Nature, 288(5789), 413-413 (1980)
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Febs Letters, 590(10), 1488-1497 (2016)
Poly (dG)-poly (dC) DNA appears shorter than poly (dA)-poly (dT) and possibly adopts an A-related conformation on a mica surface under ambient conditions
Borovok N, et al.
Febs Letters, 581(30), 5843-5846 (2007)
Ville Laitala et al.
Analytical chemistry, 77(5), 1483-1487 (2005-03-01)
We report here a novel, time-resolved, lanthanide-based energy-transfer assay utilizing nonoverlapping acceptor fluorophores, which have their absorption energetically at a higher level than the emittive transitions of the donor. The technique was studied by comparing a series of nonoverlapping acceptors

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