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PRS2099

Sigma-Aldrich

Anti-CX3CL1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CX3C, Anti-Chemokine (C-X3-C motif) ligand 1

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About This Item

MDL number:
MFCD01864668
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P78423

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CX3CL1(6376)

General description

Chemokine (C-X3-C motif) ligand 1 (CX3CL1) or fractalkine is a membrane protein and part of the CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. The protein acts as a ligand for the G-protein coupled receptor CX3CR1. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and in neurons. The gene encoding it is localized on human chromosome 16q21.

Immunogen

a peptide corresponding to 18 amino acids near the amino-terminus of human CX3CL1.

Biochem/physiol Actions

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)–dependent manner. The protein plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it may be involved in atherogenesis.

Linkage

The action of this antibody can be blocked using blocking peptide SBP2099.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Fractalkine Promotes Human Monocyte Survival via a Reduction in Oxidative Stress
Gemma E White
Arteriosclerosis, Thrombosis, and Vascular Biology, 34(12), 2554?2562-2554?2562 (2014)
Gladys Morrison et al.
Stem cell research, 16(1), 140-148 (2016-01-17)
Differentiated cells retain the genetic information of the donor but the extent to which phenotypic differences between donors or batches of differentiated cells are explained by variation introduced during the differentiation process is not fully understood. In this study, we
Zhen-Zhen Huang et al.
Brain, behavior, and immunity, 40, 155-165 (2014-04-01)
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