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PRS3953

Sigma-Aldrich

Anti-RIG-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, Anti-Dead box protein 58, Anti-Retinoic acid inducible gene 1 protein, Anti-ddx58

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

O95786

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DDX58(23586)

General description

RIG-1 (retinoic acid-inducible gene I) is a cytoplasmic viral RNA receptor, that is also known as DDX58 (DExD/H-box helicase 58). It belongs to RIG-I-like receptor (RLR) family. It has 2 N-terminal caspase recruitment domains (CARDs), a central RNA helicase domain, and a C-terminal RNA-binding domain. It is located on chromosome 9p21.1.

Immunogen

human GST-tagged RIG-1 protein.

Biochem/physiol Actions

DDX58 (DExD/H-box helicase 58) mutations leads to atypical singleton-merten syndrome. It participates in immune regulation and activation of astrocyte.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten syndrome
Jang MA, et al.
American Journal of Human Genetics, 96(2), 266-274 (2015)
Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten syndrome
Jang MA, et al.
American Journal of Human Genetics (2015)
Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate
Lee MK, et al.
Nucleic Acids Research, 44(17), 8407-8416 (2016)
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis
MacNair L, et al.
Brain, 139(Pt 1), 86-100 (2016)
Maurizio Callari et al.
Molecular oncology, 8(7), 1278-1289 (2014-05-24)
The majority of gene expression signatures developed to predict the likelihood to relapse in breast cancer (BC) patients assigns a high risk score to patients with Estrogen Receptor (ER) negative or highly proliferating tumors. We aimed to identify a signature

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