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PRS4053

Sigma-Aldrich

Anti-VISA (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CARD adapter inducing interferon-beta, Anti-MAVS, Anti-Mmitochondrial antiviral signaling protein, Anti-Virus-induced signaling adapter

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q7Z434

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAVS(57506)

General description

VISA (virus-induced signalling adaptor) is also designated as MAVS (mitochondrial antiviral signalling protein). It has 540 amino acids and three main domains such as N-terminal caspase recruitment and activation domain (CARD), an internal proline-rich region and a C-terminal transmembrane (TM) domain. It is mapped to chromosome 20p13. It is intermediately expressed in all tissues and brain regions except in fetal brain.

Immunogen

a 13 amino acid peptide from near the amino-terminus of human VISA.

Biochem/physiol Actions

VISA (virus-induced signalling adaptor) serves as an adaptor molecule for retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs). It activates intracellular signaling cascades, that leads to nuclear translocation of the transcription factors- IRF3 (interferon regulatory factor 3), IRF7 (interferon regulatory factor 7), and NF-κB (Nuclear factor-κB). It also helps in the formation of type I interferons (IFN-I) and proinflammatory cytokines.

Linkage

The action of this antibody can be blocked using blocking peptide SBP4053.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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Alteration of Antiviral Signalling by Single Nucleotide Polymorphisms (SNPs) of Mitochondrial Antiviral Signalling Protein (MAVS)
Xing F, et al.
PLoS ONE, 11(3) (2016)
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
Seth RB, et al.
Cell (2005)
VISA--a pass to innate immunity
Qi B, et al.
The International Journal of Biochemistry & Cell Biology, 39(2), 287-291 (2007)
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus
Zhang LK, et al.
Journal of Virology, 90(22), 10259-10270 (2016)
Adnan Y Chowdhury et al.
Virology, 456-457, 300-309 (2014-06-04)
We previously found that human pegivirus (HPgV; formerly GBV-C) NS3 protease activity inhibits Human Immunodeficiency Virus (HIV) replication in a CD4+ T cell line. Given the protease׳s similarity to the Hepatitis C virus (HCV) NS3 protease, we characterized HPgV protease

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