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PZ0159

Sigma-Aldrich

MCOPPB trihydrochloride hydrate

>98% (HPLC)

Synonym(s):

1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole trihydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C26H40N4 · 3 HCl · xH2O
CAS Number:
1028969-49-4
Molecular Weight:
518.01 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329823741

Quality Level

100

assay

>98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

H2O: ≥13 mg/mL

storage temp.

room temp

SMILES string

O.Cl.Cl.Cl.CC1(CCCCCCC1)N2CCC(CC2)n3c(nc4ccccc34)[C@@H]5CCCNC5

InChI

1S/C26H40N4.3ClH.H2O/c1-26(15-7-3-2-4-8-16-26)29-18-13-22(14-19-29)30-24-12-6-5-11-23(24)28-25(30)21-10-9-17-27-20-21;;;;/h5-6,11-12,21-22,27H,2-4,7-10,13-20H2,1H3;3*1H;1H2

InChI key

UQBVSGBDJOJHIP-UHFFFAOYSA-N

Biochem/physiol Actions

MCOPPB trihydrochloride is a potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. MCOPPB is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Marco Raffaele et al.
GeroScience (2021-11-26)
Accumulation of senescent cells may drive age-associated alterations and pathologies. Senolytics are promising therapeutics that can preferentially eliminate senescent cells. Here, we performed a high-throughput automatized screening (HTS) of the commercial LOPAC®Pfizer library on aphidicolin-induced senescent human fibroblasts, to identify

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