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PZ0173

Sigma-Aldrich

CP-775146

≥98% (HPLC)

Synonym(s):

(S)-2-(3-(1-(2-(4-isopropylphenyl)acetyl)piperidin-3-yl)phenoxy)-2-methylpropanoic acid

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About This Item

Empirical Formula (Hill Notation):
C26H33NO4
CAS Number:
702680-17-9
Molecular Weight:
423.54
MDL number:
MFCD19690946
UNSPSC Code:
12352200
PubChem Substance ID:
329823747
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -75 to -83° in methanol

color

white to tan

solubility

DMSO: ≥80 mg/mL

storage temp.

−20°C

SMILES string

CC(C)C1=CC=C(CC(N2CCC[C@@H](C3=CC(OC(C)(C)C(O)=O)=CC=C3)C2)=O)C=C1

InChI

1S/C26H33NO4.Na/c1-18(2)20-12-10-19(11-13-20)15-24(28)27-14-6-8-22(17-27)21-7-5-9-23(16-21)31-26(3,4)25(29)30;/h5,7,9-13,16,18,22H,6,8,14-15,17H2,1-4H3,(H,29,30);/q;+1/p-1/t22-;/m1./s1

InChI key

YQAGREGJJZRFDN-VZYDHVRKSA-M

Biochem/physiol Actions

CP-775146 is a potent and selective PPARα agonist.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Uxía Nogueira-Recalde et al.
EBioMedicine, 45, 588-605 (2019-07-10)
Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available. Our objective was to identify molecules to prevent OA by regulating chondrocyte senescence and autophagy. Human chondrocytes with IL-6 induced

Articles

Nuclear Receptors (PPARs)

Peroxisome proliferator activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors.

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