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PZ0220

Sigma-Aldrich

PF-06250112

≥98% (HPLC)

Synonym(s):

(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C22H20F2N6O2
Molecular Weight:
438.43
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

Biochem/physiol Actions

PF-06250112 is a potent inhibitor of Bruton′s tyrosine kinase (BTK). PF-06250112 blocks both B-cell receptor and FcR-mediated signaling, and prevents FcR-dependent, Antibody-mediated proteinuria in a mouse glomerulonephritis model.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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