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PZ0313

Sigma-Aldrich

PF-04802367

≥98% (HPLC)

Synonym(s):

N-(3-(1H-1,2,4-Triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide, PF 04802367, PF-367, PF-4802367

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About This Item

Empirical Formula (Hill Notation):
C16H16ClN5O3
CAS Number:
1962178-27-3
Molecular Weight:
361.78
UNSPSC Code:
12352200
PubChem Substance ID:
329823833
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

ClC1=CC(C2=C(C(NCCCN3N=CN=C3)=O)N=CO2)=CC=C1OC

InChI

1S/C16H16ClN5O3/c1-24-13-4-3-11(7-12(13)17)15-14(20-10-25-15)16(23)19-5-2-6-22-9-18-8-21-22/h3-4,7-10H,2,5-6H2,1H3,(H,19,23)

InChI key

RQFYFNAGNBUGFC-UHFFFAOYSA-N

Biochem/physiol Actions

PF-04802367 (PF-367) is a potent and specific ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3α/β) with an IC50 value of 2.3 nM and >450-fold selectivity for GSK-3 in a panel of >400 neuroreceptors, enzymes and kinases. GSK-3 dysregulation has been implicated in the pathogenesis of neurological diseases including Alzheimer′s disease.
PF-04802367 is also known as [N-(3-(1H-1,2,4-triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide) or PF-367. It regulates tau phosphorylation in the brain.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging
Liang S H, et al.
Angewandte Chemie (International Edition in English), 55(33), 9601-9605 (2016)

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