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R0655

Sigma-Aldrich

Anti-Ribosomal Protein L26 (N-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-RPL26

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About This Item

MDL number:
MFCD09265375
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 17 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

immunoprecipitation (IP): 5-10 μg using HEK-293T cell lysates
indirect immunofluorescence: 5-10 μg/mL using paraformaldehye-fixed HeLa cells
western blot: 0.5-1 μg/mL using HEK-293T cell extracts

UniProt accession no.

P61254

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RPL26(6154)
mouse ... Rpl26(19941)
rat ... Rpl26(287417)

Related Categories

General description

RPL26 (ribosomal protein L26) is located on chromosome 17. It codes for a 145-amino-acid long protein and has four exons. It is present on the large ribosomal subunit.
Ribosomal protein L26 is one of the large ribosomal subunit proteins.

Specificity

Anti-Ribosomal Protein L26 (N-terminal) specificallyrecognizes human Ribosomal Protein L26.

Immunogen

synthetic peptide corresponding to amino acids 1-17 of human ribosomal protein L26, conjugated to KLH via a C-terminal added cysteine residue. The sequence is conserved in human, rat, and mouse.

Application

Anti-Ribosomal Protein L26 (N-terminal) antibody produced in rabbit has been used in:
  • immunoblotting
  • immunoprecipitation
  • immunostaining
  • immunofluorescence
  • coimmunoprecipitation analysis

Biochem/physiol Actions

RPL26 (ribosomal protein L26) regulates the expression of p73. It plays an important role in translation and stability of ribosomes. RPL26 frameshift mutation can cause several physical abnormalities.
Ribosomal proteins are implicated in mRNA recognition, tRNA recognition and decoding and nuclear export. It was shown together with nucleolin to bind to the 5′ untranslated region of p53 mRNA and to control p53 translation and induction after DNA damage.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Molecular cloning of ribosomal protein L26 (RPL26) cDNA from Ailuropoda melanoleuca and its potential value in phylogenetic study
Hou W, et al.
Biochemical Systematics and Ecology, 36 (2008)
The social life of ribosomal proteins
Brodersen DE and Nissen P
The FEBS journal, 272(9), 2098-2108 (2005)
Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-? Peptide Generation In Vivo
Serrano-Pozo A, et al.
PLoS ONE, 12(1) (2017)
p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability
Zhang M, et al.
Oncotarget, 7(48), 78255-78268 (2016)
Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26
Ofir-RY, et al.
Molecular Cell, 32(2), 180-189 (2008)
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