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R3277

Sigma-Aldrich

Rutaecarpine

>98% (HPLC)

Synonym(s):

8,13-Dihydro­indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one, Rhetine, Rutecarpine

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About This Item

Empirical Formula (Hill Notation):
C18H13N3O
CAS Number:
84-26-4
Molecular Weight:
287.32
MDL number:
MFCD00210551
UNSPSC Code:
41116107
PubChem Substance ID:
24278677
NACRES:
NA.25

Quality Level

100

assay

>98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble 18 mg/mL (clear yellow solution)
H2O: insoluble

storage temp.

2-8°C

SMILES string

O=C1N2CCc3c([nH]c4ccccc34)C2=Nc5ccccc15

InChI

1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2

InChI key

ACVGWSKVRYFWRP-UHFFFAOYSA-N

Gene Information

human ... CYP1A1(1543) , CYP1A2(1544) , CYP1B1(1545)

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Related Categories

Biochem/physiol Actions

Delayed rectifier K+ channel blocker. Inhibits platelet aggregation; vasoldilator.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shixi Xu et al.
Journal of ethnopharmacology, 139(2), 395-400 (2011-11-29)
Wu-Chu-Yu is a well-known herbal drug used for hypertension. Rutaecarpine and evodiamine are main bioactive components of the medicine. A sensitive and specific HPLC method was developed to analyze rutaecarpine (Rut) and evodiamine (Evo) in rat whole blood. The pharmacokinetics
Yong-Tai Zhang et al.
International journal of nanomedicine, 7, 2465-2472 (2012-06-09)
To investigate the cellular uptake of evodiamine and rutaecarpine in a microemulsion in comparison with aqueous suspensions and tinctures. A microemulsion was prepared using the dropwise addition method. Mouse skin fibroblasts were cultured in vitro to investigate the optimal conditions
S N Wu et al.
Neuropharmacology, 41(7), 834-843 (2001-10-31)
The effects of rutaecarpine on ionic currents of NG108-15 neuronal cells were investigated in this study. Rutaecarpine (2-100 microM) suppressed the amplitude of delayed rectifier K+ current (I(K(DR))) in a concentration-dependent manner. The IC50 value for rutaecarpine-induced inhibition of I(K(DR))
Wenguang Yin et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 34(22), 2946-2949 (2010-03-10)
To establish a SPE-HPLC method for the determination and pharmacokinetic study of evodiamine and rutacarpine in rat plasma. A Kromasil C18 column (4.6 mm x 250 mm, 5 microm) was used with acetonitrile-water-tetrahydrofuran-acetic acid (51:48:1:0.1) as a mobile phase and
Jian-Zhe Li et al.
Canadian journal of physiology and pharmacology, 88(10), 949-959 (2010-10-22)
Dysfunction of capsaicin-sensitive sensory nerves is involved in cardiac remodeling, and rutaecarpine has been shown to exert a beneficial effect on cardiac function through activating the sensory nerves. This study was conducted to explore the potential inhibitory effect of rutaecarpine
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