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R5278

Sigma-Aldrich

Anti-RAGE (Receptor for Advanced Glycation Endproducts) antibody produced in rabbit

affinity isolated antibody

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About This Item

MDL number:
MFCD03097203
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, rat

technique(s)

immunohistochemistry: 1-2 μg/mL using transgenic mouse retina
western blot: 1 μg/mL using using mouse lung extract

UniProt accession no.

Q63495

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AGER(177)
mouse ... Ager(11596)
rat ... Ager(81722)

General description

Receptor for advanced glycation end products (RAGE), also known as advanced glycosylation end-product specific receptor (AGER) is encoded by the gene mapped to human chromosome 6p21. The encoded protein is a member of the immunoglobulin superfamily of cell surface molecules.

Immunogen

synthetic peptide corresponding to amino acid residues 362-380 from rat RAGE. This sequence is 100% conserved in mouse and 70% conserved in human.

Application

Anti-RAGE (Receptor for Advanced Glycation Endproducts) antibody produced in rabbit has been used in western blot and flow cytometry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

The soluble form of receptor for advanced glycation end products (RAGE) has a function in the Wnt pathway. RAGE has a role in the development of inflammatory and cellular damage, as well as cellular toxicity. It has been associated with diabetic atherosclerosis. AGER/RAGE also modulates cell proliferation, differentiation and apoptosis.{93

Physical form

Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

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flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Susmita Barman et al.
Chemico-biological interactions, 307, 37-50 (2019-04-23)
Zinc depletion during diabetes postulates a role for zinc nutrition in the management of associated complications. The present study evaluated zinc supplementation for countering the compromised intestinal integrity through moderation of oxidative stress and suppression of stress-stimulated inflammatory proliferation in
Pradeep, S. R., & Srinivasan, K. (2018). Alleviation of oxidative stress-mediated nephropathy by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) in streptozotocin-induced diabetic rats.
Pradeep S R and Srinivasan K
Food & Function (2018)
Genome-wide association studies of asthma.
Tamari M, et al.
Allergology International, 60(3), 247-252 (2011)
An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients.
Liao Y, et al.
Reproductive Biology and Endocrinology, 15(1), 9-9 (2017)
Association of RAGE gene Gly82Ser polymorphism with coronary artery disease and ischemic stroke
Ma W Q, et al.
Medicine, 95(49) (2016)
View All Related Papers

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