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R5903

Sigma-Aldrich

Anti-Rab11 antibody produced in rabbit

1 mg/mL, affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
MFCD01322583
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

concentration

1 mg/mL

technique(s)

western blot: 6.6 μg/mL using HeLa cell extract

UniProt accession no.

P62491

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RAB11A(8766)
mouse ... Rab11a(53869)
rat ... Rab11a(81830)

General description

Rab11 (Ras-related protein) has three subtypes -Rab11a, Rab11b, and Rab25. Rab11a (Ras-related protein Rab-11A) belongs to the ras-like small GTP-binding protein superfamily. It is found in nonpolarized cells like fibroblasts and erythroleukemia cells. It is located on human chromosome 15q21.3-q22.31 and on mouse chromosome 9. Rab11a is expressed abundantly.

Immunogen

synthetic peptide corresponding to amino acid residues 1-17 from human Rab11. This sequence is completely conserved in human, mouse, and rat and 94% conserved in C. elegans and amphibians.

Application

Anti-Rab11 has been used in western blotting and immunohistochemistry.

Biochem/physiol Actions

Rab11a (Ras-related protein Rab-11A) participates in the modulation of basolateral to apical transcytosis. It controls TRPV5/6 (Ca2+-selective members) channel trafficking. It is essential for the production of bile canalicular in WIF-B9 cells (rat hepatoma/human fibroblast hybrid cells).

Physical form

Solution in phosphate buffered saline containing 1 mg/mL bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells
Wakabayashi Y, et al.
Proceedings of the National Academy of Sciences of the USA, 15087-92, 15087-15092 (2005)
Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane
van de Graaf SF, et al.
Molecular and Cellular Biology, 26(1), 303-312 (2006)
O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function
Muller J, et al.
PLoS ONE, 9(2) (2014)
Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells
Kallquist L, et al.
Experimental Cell Research, 316(19), 3182-3196 (2010)
Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins
Gromov PS, et al.
Febs Letters, 429(3), 359-364 (1998)
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