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RAB0460

Sigma-Aldrich

Human TGF-β 1 ELISA Kit

for serum, plasma, and cell culture supernatants

Synonym(s):

TGF-beta-1, Transforming growth factor beta-1

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
capture ELISA: suitable

input

sample type serum
sample type cell culture supernatant(s)
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/mL
standard curve range: 0.0823-60 ng/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TGFB1(7040)

Related Categories

General description

The Human TGF-β 1 ELISA (Enzyme-Linked mmunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human TGF-β 1 in serum, plasma, cell culture supernatants.

Immunogen

Recombinant Human TGF-β 1

Application

For research use only. Not for use in diagnostic procedures.
Human transforming growth factor-β1 (TGF-β1) ELISA Kit has been used to measure level of TGF-β1 released from tubular cells.

Biochem/physiol Actions

Transforming growth factor-β1 (TGF-β1) is a pluripotential cytokine that plays a vital role in the homeostasis of peripheral CD4+CD25+ regulatory T cells and regulation of FOXP3 (forkhead box P3) expression in vivo. Binding of TGF-β1 to its receptor, activates members of the SMAD protein family involved in gene regulation. Study shows that reduced expression of circulating transforming growth factor-β1 (TGF-β1) might contribute to systemic lupus erythematosus (SLE) development. Polymorphism of TGF-β1 is associated with pathogenesis of rheumatoid arthritis (RA) and pneumoconiosis. Serum TGF-β1 expression is elevated in systemic sclerosis (SSc) patients. Serum TGF-β1 functions as a potential biomarker of Guillain-Barré syndrome (GBS) and SSc.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)SDS
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible, corrosive hazardous materials

wgk_germany

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Reassessing the Role of the Active TGF-?1 as a Biomarker in Systemic Sclerosis: Association of Serum Levels with Clinical Manifestations.
Dantas AT
Disease Markers (2016)
Association between circulating transforming growth factor-?1 level and polymorphisms in systemic lupus erythematosus and rheumatoid arthritis: A meta-analysis.
Lee YH and Bae SC
Cellular and molecular biology (Noisy-le-Grand, France), 63(1), 53-59 (2017)
Increased serum concentrations of transforming growth factor-?1 (TGF-?1) in patients with Guillain-Barre syndrome.
Chang KH
Clinica Chimica Acta; International Journal of Clinical Chemistry, 461, 8-13 (2016)
Association between Genetic Variants of Transforming Growth Factor-?1 and Susceptibility of Pneumoconiosis: A Meta-analysis.
Deng CW
Chinese Medical Journal (English Edition), 130(3), 357-364 (2017)
XueXuan Zhang et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 59, 110-117 (2017-04-19)
To investigate PI3K-Akt-mTOR signaling pathway changes and the proliferation of FoxP3+Treg cells in patients with active tuberculosis. We isolated PBMCs and CD4+CD25+FoxP3+Treg cells from peripheral blood collected from patients with active tuberculosis and healthy controls. We compared the proportion and
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