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S1701

Sigma-Aldrich

Anti-SDCBP antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-MDA-9, Anti-Melanoma differentiation associated protein-9, Anti-Pro-TGF-alpha cytoplasmic domain-interacting protein 18, Anti-Scaffold protein Pbp1, Anti-ST1, Anti-SYCL, Anti-Syndecan binding protein (syntenin), Anti-Syntenin, Anti-TACIP18

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

form

buffered aqueous solution

mol wt

antigen ~30 kDa

species reactivity

mouse, human, rat

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 10-20 μg using lysates of human HeLa cells
indirect immunofluorescence: 2-5 μg/mL using human HeLa cells
western blot: 2-4 μg/mL using whole extract of human HEK-293T cells, rat NRK cells, or mouse Neuro-2a cells

UniProt accession no.

O00560

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SDCBP(6386)

General description

Syndecan binding protein (SDCBP), also known as syntenin and melanoma differentiation associated gene-9 (mda-9), was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. SDCBP contains tandemly repeated PDZ domains that binds the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. SDCBP is primarily localized to membrane associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus.

Application

Anti-SDCBP antibody produced in rabbit has been used in:
  • enzyme linked immuno sorbent assay (ELISA)
  • immunoblotting
  • immunocytochemistry

Biochem/physiol Actions

Syndecan binding protein (SDCBP) regulates cytoskeletal-membrane organization, cell adhesion, protein trafficking and the activation of transcription factors. SDCBP promotes metastasis in human melanoma cells by activating c-Src.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Devanand Sarkar et al.
Cancer research, 68(9), 3087-3093 (2008-05-03)
Cancer is a progressive disease that, in many instances, if untreated, can culminate in metastatic spread of primary tumor cells to distant sites in the body. Metastasis frequently confers virulence and therapy resistance to cancer cells, and defining the molecular

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