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S4813

Sigma-Aldrich

Anti-α1-Syntrophin (RA-16) antibody produced in rabbit

buffered aqueous solution, IgG fraction of antiserum

Synonym(s):

Anti-SNTA1

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About This Item

MDL number:
MFCD03454688
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 60 kDa

species reactivity

rat

technique(s)

immunohistochemistry (frozen sections): suitable using 0.5% paraformaldehyde fixed/0.5% Triton X-100 treated rat skeletal muscle
microarray: suitable
western blot: 1:2,000 using rat skeletal muscle homogenate extract (membrane fraction)

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Snta1(20648)
rat ... Snta1(362242)

Related Categories

General description

α1-syntrophin (SNTA1) is a dystrophin-associated protein, that has four domains- a postsynaptic density protein-95/disc large/zona occludens-1 (PDZ) domain, two pleckstrin homology (PH1 and PH2) domains and a syntrophin unique (SU) domain. It is located on human chromosome 20q11.2. It is usually present in the peripheral cytoplasmic membrane.
Anti-α1-Syntrophin (RA-16) is developed in rabbit using a synthetic peptide corresponding to a sequence of mouse α1-syntrophin The syntrophins are a family of intracellular peripheral membrane proteins (58-60 kDa), comprising at least three isoforms α1, β1, and β2-syntrophins. Syntrophins in mammalian skeletal muscle have been shown to be part of a complex of proteins associated with dystrophin, the product of Duchenne/Becker muscular dystrophy gene. The C-terminal 57 amino acids region of syntrophins is highly conserved among the three isoforms, and may contain the binding site for dystrophin.

Immunogen

synthetic peptide corresponding to a sequence of mouse α1-syntrophin (amino acids 191-206 with N-terminally added lysine) conjugated to KLH.

Application

Anti-α1-Syntrophin (RA-16) antibody produced in rabbit has been used in immunohistochemistry and immunoblotting.

Biochem/physiol Actions

α1-Syntrophin recruit signaling proteins(2) to the membrane via association with the dystrophin complex.
α1-syntrophin (SNTA1) mutations results in LQTS (cardiac channelopathies like long QT syndrome). It modulates the development of adipocyte lipid droplet. It also participates in the survival signaling pathway in myoblasts. α1-syntrophin controls voltage-gated Na+ channels. It acts as a substrate for stress-activated protein kinase-3 (SAPK-3).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current
Cheng J, et al.
Circulation. Arrhythmia and Electrophysiology, 2(6), 667-676 (2009)
?1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current
Choi JI, et al.
PLoS ONE, 11(3) (2016)
?-Syntrophin is involved in the survival signaling pathway in myoblasts under menadione-induced oxidative stress
Lim JA, et al.
Experimental Cell Research, 344(1), 1-10 (2016)
The adaptor protein alpha-syntrophin regulates adipocyte lipid droplet growth
Eisinger K, et al.
Experimental Cell Research, 345(1), 100-107 (2016)
Clinical utility gene card for: long-QT syndrome (types 1-13)
Beckmann BM, et al.
European Journal of Human Genetics, 21(10) (2013)
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