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SAB1300896

Sigma-Aldrich

Anti-LECT2 (N-term) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-HLECT2, Anti-LECT2, Anti-Leukocyte cell-derived chemotaxin 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000

NCBI accession no.

NP_002293

UniProt accession no.

O14960

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LECT2(3950)

Related Categories

General description

Leukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine, encoded by the gene mapped to human chromosome 5q31.1–q32. The gene spanning ~8kb of genomic DNA contains four exons and three introns. LECT2 is a secreted protein with a molecular mass of 16kDa. The encoded protein is mainly expressed in vascular, endothelial and smooth muscle cells, adipocytes, cerebral nerve cells, apical squamous epithelia, parathyroid cells, sweat, sebaceous glandular epithelia and Hassall bodies. Additionally, it is also expressed at high levels in fetal and adult liver.

Immunogen

LECT2 (NP_002293, 34-68)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human LECT2.

Biochem/physiol Actions

Leukocyte cell-derived chemotaxin 2 (LECT2) acts as a chemotactic factor for neutrophils. It is also implicated in the inflammatory response and insulin resistance. Low serum LECT2 level increases the risk of susceptibility to diabetic retinopathy (DR). Overexpression of the gene has been observed in circulating plasma of non-alcoholic fatty liver disease (NAFLD) patients.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene.
Yamagoe S
Genomics, 48, 324-329 (1998)
Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection.
Jeronimo SM
Genes and Immunity, 8(7), 539-551 (2007)
Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis.
Yoo HJ
PLoS ONE, 12 (2017)
Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection.
Jeronimo SM
Genes and Immunity, 8, 539-551 (2007)
Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene.
Yamagoe S
Genomics, 48(3), 324-329 (1998)
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