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SAB1400494

Sigma-Aldrich

Anti-ANKRD1 antibody produced in mouse

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-ALRP, Anti-C-193, Anti-CARP, Anti-CVARP, Anti-MCARP, Anti-bA320F15.2

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About This Item

MDL number:
MFCD00164711
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect immunofluorescence: suitable
western blot: 1 μg/mL

UniProt accession no.

Q15327

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ANKRD1(27063)

General description

Ankyrin repeat domain-containing protein 1 (ANKRD1) is a member of muscle ankyrin repeat protein. It comprises a nuclear localization signal, four repeats of an ankyrin motif, and a PEST-like sequence. The ANKRD1 gene is mapped to human chromosome 10q23.31. It is expressed in skeletal and cardiac muscles.
The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. (provided by RefSeq)

Immunogen

ANKRD1 (NP_055206.2, 1 a.a. ~ 319 a.a) full-length human protein.

Sequence
MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF

Biochem/physiol Actions

Ankyrin repeat domain-containing protein 1 (ANKRD1) acts as a transcriptional regulator for cardiomyogenesis. It interacts with calsequestrin-2, intermediate filament protein desmin, and with Y-box transcription factor 1 (YB-1). Elevated expression of ANKRD1 is implicated in idiopathic dilated cardiomyopathy. The hepatitis C virus (HCV) coordinates with ANKRD1 for its entry and propagation. It serves as a co-activator of the p53 tumor suppressor protein and may regulate apoptosis in human ovarian cancer cells.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thoa T Than et al.
Scientific reports, 6, 20819-20819 (2016-02-11)
Hepatitis C virus (HCV) is highly dependent on host proteins for its own propagation. By transcriptome sequencing (RNA-Seq) analysis, we identified 30 host genes that were significantly differentially expressed in cell culture-grown HCV (HCVcc)-infected cells. Of these candidate genes, we
Akiko Takahashi et al.
Scientific reports, 8(1), 14896-14896 (2018-10-07)
Overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is critical in combating EGFR-mutant non-small cell lung cancer (NSCLC). We tried to construct a novel therapeutic strategy to conquer the resistance to second-and third-generation EGFR-TKIs in EGFR-positive

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